Search results for "Chemical products"
showing 3 items of 3 documents
Retention increments of isomeric chlorobenzenes
1983
The chlorobenzene isomers are used extensively as intermediates in a wide range of chemical products. More recently their determination in environmental situations has become of considerable importance and chromatographic procedures have been widely reported for their determination in both trace and major amounts. There are over 220 publications in which gas chromatography (GC) has been applied to the analysis of chlorobenzene. However, over 60 o/o of these works refer to the separation of only one isomer. Relatively few publications’-8 consider all the isomers, although the use of both capillary3’ and packedcolumns with polar and non-polar stationary phases has been reported. Temperature p…
Human primary macrophages scavenge AuNPs and eliminate it through exosomes. A natural shuttling for nanomaterials.
2018
Abstract The use of nanomaterials is increasing but the real risk associated with their use in humans has to be defined. In fact, nanomaterials tend to accumulate in organs over a long period of time and are slowly degraded or eliminated by the body. Exosomes are nanovesicles actively shuttle molecules, including chemical products and metals, through the body. Macrophages scavenge the body from both organic and inorganic substances, and they use to release high amounts of exosomes. We hypothesized that macrophages may have a role in eliminating nanomaterials through their exosomes. We treated human primary macrophages with 20 nm gold nanoparticles (AuNPs), analyzing the presence of AuNPs in…
Quantification of HSP27 and HSP70 Molecular Chaperone Activities
2011
Stress-inducible heat-shock proteins (HSPs, like HSP70 and HSP27) are molecular chaperones that -protect cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. HSP27 and HSP70 chaperone activities are useful indicators to test chemical products and physical stress impact on protein denaturation, to select HSP inhibitors, or to -determine the implication of the chaperone function in other HSP activities, such as apoptosis. We have developed two simple and fast chaperone activity tests for HSP27 and HSP70 that we initially set up to test the effect of potential HSP inhibitors obtained after screening of chemical an…